Posts Tagged ‘IVF outcome’

Improving IVF outcomes in women with endometriosis

Monday, September 13th, 2010

It has been known for some time that women with endometriosis have had a poorer prognosis for success with IVF than women who do not suffer from the condition.

In an attempt to reverse this negative effect from endometriosis, several strategies have been employed including  surgery to remove endometriomas and cauterize endometrial implants and pretreatment before the IVF cycle with prolonged Lupron or drugs like letrozole and norethindrone.

Now a study reported in the August 2010 issue of Fertility & Sterility shows that six to eight weeks of pretreatment with birth control pills gives women with endometriosis the same chance of success as women having IVF for other reasons. The study also concluded that the prolonged regimen of birth control pills did not adversely affect egg production.

It sounds almost too good to be true. As we start to use this simple method of pretreatment we will get a sense if it works out as well as this study claims.

Obesity impairs IVF success

Monday, March 8th, 2010

One of the issues I discuss with new patients when it's pertinent is weight loss in order to improve the chance of IVF success.

The latest evidence supporting this is in an article in the February 2010 edition of Fertility & Sterility looking at the outcomes in different groups based on BMI (body mass index as kilograms per square meter). They compared lean (<20 kg/m2); normal (20–24.9 kg/m2); overweight (25–29.9 kg/m2); and obese (≥30 kg/m2) women in 6500 IVF cycles. Although there was no difference in insemination procedure, fertilization rate, day of transfer, mean number of embryos transferred and cryopreserved embryos, percentage of blastocyst transfers, or embryo quality on day 2 and 3 among groups, pregnancy and live birth rates were reduced progressively with each category of increase in BMI. In addition, the cumulative pregnancy rate after four IVF cycles was reduced as BMI increased.

This confirms other studies that being obese or even just overweight overweight has a negative effect on IVF success.