PCOS Beyond Infertility

Last week I wrote about the effect polycystic ovarian syndrome (PCOS) has on a woman’s fertility and how Clomid is very effective in overcoming issues with ovulation. But there are many androgen hormone effects of PCOS that can affect a woman’s general health. These issues are well outlined in an online article on U.S News.

PCOS, which affects about 15 …

PCOS, Clomid and Infertility

Here’s breaking news….that we have know for about 50 years.

Clomid (clomiphene citrate) (CC) significantly improved ovulation and pregnancy outcomes in women with polycystic ovarian syndrome (PCOS), according to data from 72 women. The part we did not know is how it works. Now there is evidence that Clomid improved markers of PCOS. Nitric oxide (NO), interleukin-10 (IL-10), and matrix …

Clomid or Gonadotropins

When considering treatment for-non-ovulating women with normal pituitary hormones, a decision must be made about which type of drug to use to enhance the chances of success: oral agents like CLOMID® (clomiphene citrate) or FEMARA® (letrozole) or injectables represented by a variety of gonadotropins, MENOPUR® (menotropins for injection), GONAL-F® (follitropin alfa for injection), BRAVELLE® (urofollitropin), and FOLLISTIM® (follitropin beta injection). …

The Evolution of Fertility Treatment

This year marks the 50th anniversary of the U.S. Food and Drug Administration approving the sale and marketing of clomiphene citrate (Clomid) for the “treatment of ovulatory dysfunction in women desiring pregnancy”.   At the time, this was a huge breakthrough for couples who were desperate to conceive their own child.  For many patients, it was a “wonder drug”.

Prior to …

Letrozole may be better than Clomid for women with PCOS

Letrozole (Femara) was associated with roughly a 42% increase in the pregnancy rate, compared with clomiphene citrate (Clomid) in infertile women with polycystic ovary syndrome in a double-blind, randomized study.

The pregnancy rate was 61.2% with letrozole versus 43% with clomiphene. There also was a trend toward more live births with letrozole (48.8% vs. 35.4%).

“We now have convincing evidence …

Minimal Stimulation IVF: Milder, Cheaper…and Less Successful

An article in the March 10th edition of the Wall Street Journal reports that the Society for Assisted Reproductive Technology plans to report so-call minimal stimulation IVF cycles separately from traditional medicated cycles.

The Society for Assisted Reproductive Technology says it will break out success rates for minimal-stimulation cycles in its 2014 statistics, which will be released in 2016. But …

Is IVF the correct first treament for unexplained infertility?

This is one of a series of news items from abstracts of studies presented at the Annual Meeting of the American Society for Reproductive Medicine as complied by Dr. David Meldrum, Scientific Director of Reproductive Partners. We appreciate the enormous amount of work it takes to compile and comment on these abstracts.


 Women over 38 with at least

What treatment works best for PCOS?

Polycystic Ovarian Syndrome (PCOS) is a condition that involves a combination of symptoms including irregular or absent cycles and male-type hormone (androgen) symptoms, Many women with PCOS also have difficulty controlling their weight. Treaments recommended for PCOS vary widely ranging from drugs like metformin designed to reduce resistance to the hormone insulin which is thought to be a cause of …