www.reproductivepartners.com

My wife and I are seeing an RE, and have tried multiple IVF cycles. Most recently the conclusion seems to be that her egg quality is being affected by an early spike in progesterone before her eggs are fully mature on a lupron protocol (10 iu daily) that should be suppressing the progesterone. The level jumped from 1.7 to 3.5 between days 7 and 8 of her last egg retrieval cycle..

My questions are:

1) what type of testing could be done to try to determine the root cause of this early progesterone spike?

2) is there any other way to regulate this type of thing through diet or medication?

3) any other recommendations on how to approach this problem?

Thank you so much for your time!

The effect of premature progesterone production is more on the lining than the eggs and so the first logical measure would be to freeze all the embryos.

To counter the progesterone rise you could take the higher dose of Lupron (to the 10 mark-20iu) or use an antagonist instead like Ganirelix or Cetrotide or use gonadotropins with less LH (less Menopur).

Arthur L. Wisot, M. D.
Reproductive Partners Medical Group
Redondo Beach, California