PGD test same abnormality
Posted: Wed Jul 29, 2015 8:53 am
Hi Dr. Wisot
I went through an IVF cycle to freeze embryos. I'm 38. FSH 7.7 AMH 4.8. I had 16 follicles total. I'm not polycystic. We did the antagonist approach. Started with 175 Gonal-f and 150 Menopure. On day 5 my e2 went up to 1095 and my Dr dropped my Gonal-f to 150 and Menopure kept on 150. I had 11 days of stimulation and on day 10 my e2 went up to 5500. My follicle count was total of 26. Only 14 were mature We did the Lupron trigger shot. We retrieved 14 mature follicles. All 14 were fertilized. On day 6, six of them were full blasts and biopsied. Here is the PGD result:
4AB monosomy 21,
4AA normal,
4AA monosomy 22,
4AB trisomy 21, monosomy 22,
4BB monosomy 22,
4BC monosomy 21,
I had the Karyotype test and I am normal. I don't have the Chromosome 21, 22 karyotype.
The sperm is from a sperm bank and does not have it either. His Chromosome test was also normal.
What could this be? You had mentioned to a patient once that this could be a "processing error" . What is that? Could this be due to poor lab? Poor PGD testing? Too much stimulation medicine on my body? The rise on e2 to 6000 caused it?
Thank you
Cindy
I went through an IVF cycle to freeze embryos. I'm 38. FSH 7.7 AMH 4.8. I had 16 follicles total. I'm not polycystic. We did the antagonist approach. Started with 175 Gonal-f and 150 Menopure. On day 5 my e2 went up to 1095 and my Dr dropped my Gonal-f to 150 and Menopure kept on 150. I had 11 days of stimulation and on day 10 my e2 went up to 5500. My follicle count was total of 26. Only 14 were mature We did the Lupron trigger shot. We retrieved 14 mature follicles. All 14 were fertilized. On day 6, six of them were full blasts and biopsied. Here is the PGD result:
4AB monosomy 21,
4AA normal,
4AA monosomy 22,
4AB trisomy 21, monosomy 22,
4BB monosomy 22,
4BC monosomy 21,
I had the Karyotype test and I am normal. I don't have the Chromosome 21, 22 karyotype.
The sperm is from a sperm bank and does not have it either. His Chromosome test was also normal.
What could this be? You had mentioned to a patient once that this could be a "processing error" . What is that? Could this be due to poor lab? Poor PGD testing? Too much stimulation medicine on my body? The rise on e2 to 6000 caused it?
Thank you
Cindy