All abnormal PGS
Posted: Thu Aug 27, 2015 6:32 pm
Hello- me and my hubby are both 32. I have PCOS, I was quite overweight through most of my 20s but lost 80lbs through weight loss surgery and am now a normal weight. My AMH is 3.6 (I think). I don't know my fsh, but I was told all was normal. We've been told we needed ivf because of my husband's sperm count. It was between 13 mil to 17 mil with low motility and morphology of 0-1%. We had an re recommend clomid for him. After 9 months of unmonitored use, his sperm count went to essentially 0. New RE recommended Varicocele repair. One year laterHis sperm count has never fully recovered, but we've gotten it up to 6 mil with decent 12ish % motility. His DFI was also tested and came back at 7%.
Ivf#1 was bcp, follistim, menopure, ganirelix and hcg trigger. We had 24 eggs, 18 mature and 16 fertilized. We ended up with 7 embryos but they were highly fragmented. 2 were "beautiful" quality and we did an eSet. It ended in a CP. Ivf#2 was a long lupron protocol with 1/2 dose menopure. We had 25 eggs, 21 mature and they all fertilized. Day 5 had 7 beautiful blasts with 4 even hatching this time. PGS results came back all abnormal. I don't know the specifics of the abnormalities except that they were all over the place. No pattern to them that would lead them to know if it was egg or sperm. The clinic graciously offered to test our remaining embryo from the first cycle, but we don't have the results yet. One quirk with this cycle was that Hubby's fresh sample was really low, so they used a back up sample. Unbeknowst to me at the time, they used a sample from before his varicocele surgery.
So, to my question. They're now telling us it has to be an egg issue and are recommending egg donor. I'm a bit baffled because of my age, although I know the pcos is a factor. I'm also a bit confused because they told us it had to his sperm after the first try. I'm wondering if you have an opinion regarding their recommendation? I'm actually OK with the idea of egg donor due to some family health issues, but I'm just scared that the eggs aren't the problem. However my RE feels strongly that because of the high quality of the embryos that it is much more likely to indicate an egg problem.
Thank you in advance for your time!
Ivf#1 was bcp, follistim, menopure, ganirelix and hcg trigger. We had 24 eggs, 18 mature and 16 fertilized. We ended up with 7 embryos but they were highly fragmented. 2 were "beautiful" quality and we did an eSet. It ended in a CP. Ivf#2 was a long lupron protocol with 1/2 dose menopure. We had 25 eggs, 21 mature and they all fertilized. Day 5 had 7 beautiful blasts with 4 even hatching this time. PGS results came back all abnormal. I don't know the specifics of the abnormalities except that they were all over the place. No pattern to them that would lead them to know if it was egg or sperm. The clinic graciously offered to test our remaining embryo from the first cycle, but we don't have the results yet. One quirk with this cycle was that Hubby's fresh sample was really low, so they used a back up sample. Unbeknowst to me at the time, they used a sample from before his varicocele surgery.
So, to my question. They're now telling us it has to be an egg issue and are recommending egg donor. I'm a bit baffled because of my age, although I know the pcos is a factor. I'm also a bit confused because they told us it had to his sperm after the first try. I'm wondering if you have an opinion regarding their recommendation? I'm actually OK with the idea of egg donor due to some family health issues, but I'm just scared that the eggs aren't the problem. However my RE feels strongly that because of the high quality of the embryos that it is much more likely to indicate an egg problem.
Thank you in advance for your time!