Aspirin may help women get pregnant quicker after miscarriage

That’s the good news. The bad news that the intent of the study was to see if aspirin reduced inflammation would it reduce the chance of repeat miscarriage and it didn’t.

A group of women who took low-dose aspirin prior to conception took less time to become pregnant compared with women who took a placebo, according to results of the Effects of Aspirin in Gestation and Reproduction (EAGER) trial.

“It was a surprising finding, but it’s premature to have a take-home message for the everyday clinic,” Robert Silver, MD, chief of maternal-fetal medicine, from the University of Utah in Salt Lake City, told Medscape Medical News. “Our study was designed to assess whether preconception treatment with low-dose aspirin would reduce the risk of pregnancy loss in women with previous pregnancy loss, and the answer is it doesn’t.”

The researchers conducted a prospective, randomized, double-blind, placebo-controlled trial in which they recruited women aged 18 to 40 years with 1 or 2 prior pregnancy losses who were still trying to conceive.

The women were randomly assigned to receive either low-dose (81 mg) aspirin or placebo through 6 menstrual cycles. All patients also received 400 μg of folic acid. If patients had a positive pregnancy test or confirmed pregnancy, treatment and follow-up continued through the pregnancy.

Daily low-dose aspirin use led to a significant decrease in time to pregnancy among women with prior losses and to a shorter time to clinically confirmed pregnancy among women with a single documented loss at less than 20 weeks during the past year. However, differences were not significant in the broader cohort.

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