Eggs made in the laboratory…in mice

An article in the October 5, 2012 Wall Street Journal reports that Japanese scientists have made mouse eggs capable of being fertilized.

The experiment completes a long-sought quest in reproductive biology: to make sperm and eggs in a lab dish. A year ago, the same core group of scientists at Kyoto University created healthy mouse sperm in the lab.

In the latest experiment, the dish-created eggs were fertilized with natural mouse sperm to create healthy, fertile mice. The research appears in the journal Science.

 
They caution that this technique that produced these mice may not work in other mammals.

Making mouse eggs "was a little harder to do," said Katsuhiko Hayashi, the lead author of the Science paper. Unlike sperm, he said, egg cells are "big and fragile, and they get mature only after a long, complex process."

It will be even tougher to repeat the trick in people. But if it can ever be done, it has the potential to transform reproductive medicine by enabling both infertile men and women to conceive their own genetic offspring.

Any such advance would also raise thorny ethical questions. In theory, at least, it would allow a man or woman of any age—or even someone who is dead but whose tissues are preserved—to become a parent.

If you will be needing donor eggs in the next decade I would not recommend waiting for this technology to be available in humans if it ever will be. The best approach today is to use frozen donor eggs through donor egg banks like Donor Egg Bank USA. Using frozen donor eggs makes the process much cheaper and quicker than fresh eggs.,