Archive for the ‘RPMG News’ Category

Can embryos created by frozen (vitrified) eggs be re-frozen?

Monday, May 14th, 2012

This is one of a series of news items from abstracts of studies presented at the Annual Meeting of the American Society for Reproductive Medicine as complied by Dr. David Meldrum, Scientific Director of Reproductive Partners. We appreciate the enormous amount of work it takes to compile and comment on these abstracts.


According to a study reported at ASRM the answer is yes.

Vitrified embryos resulting from vitrified eggs achieved the same ongoing pregnancy and delivery rates as vitrified embryos from fresh eggs. These data further support the use of egg vitrification with multiple freeze all cycles for poor responders to allow for one ICSI procedure, and for freeze all of high responders to limit excess embryos and difficult decisions by the couple once they complete their family with the disposition of unused embryos that have created.

In addition it will be useful for recipients of vitrified frozen donor eggs if they create more embryos than they wish to transfer in that cycle.

Are frozen eggs as good as fresh in creating IVF pregnancies?

Monday, April 30th, 2012

This is one of a series of news items from abstracts of studies presented at the Annual Meeting of the American Society for Reproductive Medicine as complied by Dr. David Meldrum, Scientific Director of Reproductive Partners. We appreciate the enormous amount of work it takes to compile and comment on these abstracts.

As egg freezing becomes more widely available, the most obvious question is whether frozen eggs are as good as fresh in creating IVF pregnanciies.

When live birth rates per egg retrieved were analyzed for both frozen eggs and for fresh IVF, they were similar (4.5 and 5.1%), indicating that egg freezing is not less efficient. Some have have even advocated egg rather than embryo cryopreservation for their multiple freeze-all cycles in poor responders in order to do one ICSI,, and for freeze-all for high responders to avoid the problem of excess embryos and to increase the likelihood of excess eggs being donated. This abstract and the finding that the pregnancy rate with donated eggs is equal whether fresh or vitrified both support their approach.

This study is reassuring for women freezing their eggs for fertility preservation as well as potential recipients of egg donation who may be planning to access frozen egg banks because of convenience and lower cost.


Can embryo co-culture overcome embryo quality issues?

Monday, April 16th, 2012

 This is one of a series of news items from abstracts of studies presented at the Annual Meeting of the American Society for Reproductive Medicine as complied by Dr. David Meldrum, Scientific Director of Reproductive Partners. We appreciate the enormous amount of work it takes to compile and comment on these abstracts.


One of the most difficult issues to overcome is persistent poor embryo quality. For some time Reproductive Partners has  been using embryo co-culture (cultureing the embryos along with other cells just as occurs in the body) as one of our startegies to improve embryo quality. Now a study reported at ASRM supports this practice.

Eggs were randomized between regular culture and co-culture using autologous clusters of granulosa cells (the cells that surround the egg in that patient's body). Day 3 embryos had improved morphology, more developed to day 5 and more were chosen for transfer. As with other studies of cumulus co-culture, improved embryo morphology was confirmed. It could be considered in any case where reduced embryo morphology has been previously observed or when reduced egg quality is expected.

Is the male partner’s age a factor in fertility?

Monday, April 2nd, 2012

This is one of a series of news items from abstracts of studies presented at the Annual Meeting of the American Society for Reproductive Medicine as complied by Dr. David Meldrum, Scientific Director of Reproductive Partners. We appreciate the enormous amount of work it takes to compile and comment on these abstracts.


Until recently there has been little evidence that the age of the male partner had a role in IVF success. Now in cases of egg donation where egg quality from young donors should be consistently good, the malke partner's has been identified as a factor in unsuccessful cycles.

Failure to conceive with oocyte donation was associated with male age and strict morphology on semen analysis. Other studies have also shown an effect of male age. Aging may be related to subtle or frank DNA fragmentation, as a number of studies have shown increased fragmentation with age. Antioxidants and frequent ejaculations prior to producing the specimen for the IVF cycle is advisable, particularly for males over age 40.

Dr. Wisot quoted in National Enquirer

Friday, March 23rd, 2012

RPMG's Dr. Arthur Wisot was quoted again the the April 2nd edition of the National Enquirer and this time it has nothing to do with fertility.

More on diet, lifestyle, men’s fertility and sperm health

Friday, March 23rd, 2012

This is one of a series of news items from abstracts of studies presented at the Annual Meeting of the American Society for Reproductive Medicine as complied by Dr. David Meldrum, Scientific Director of Reproductive Partners. We appreciate the enormous amount of work it takes to compile and comment on these abstracts.


Intake and levels of trans fats were negatively correlated with sperm concentration. Findings in animals suggest a direct negative impact rather than trans fat intake being simply correlated with a poorer diet in general. The predominant source of trans fats is from doughnuts, French pastries and fried foods. When a nutritional label is not present, buyer beware.

Regular exercise was examined as a factor influencing semen quality. Men who exercised regularly had significantly higher motility. Moderate exercise decreases oxidative stress by increasing endogenous antioxidant enzymes such as para-oxinase-1 (PON-1) and superoxide dismutase (SOD) and increases vascular nitric oxide and flow-mediated dilation. Both improved antioxidant defenses and increased testicular blood flow could improve sperm function. It is interesting that the factors supporting improved erectile function completely parallel factors improving sperm function.

Bottom line: Excecise regularly and eat well. Have you ever heard this advice before?

Can too much exercise impair fertility?

Tuesday, March 20th, 2012

According to  new study from Boston University measuring the effect of various exercise levels on fertility rates in Danish women and published in  Fertility & Sterility, there was evidence for a dose-response relationship between increasing vigorous physical activity and delayed time to pregnancy in all subgroups of women with the exception of overweight and obese women. Moderate physical activity was associated with a small increase in fertility regardless of BMI. These findings indicate that physical activity of any type might improve fertility among overweight and obese women, a subgroup at higher risk of infertility. On the other hand, lean women who substitute vigorous with moderate physical activity may also improve their fertility.

A previous Harvard study was defining vigorous expercise as > 3 hr/week. This one is > or = 5 hr/week so the breakpoint is around 4-5 hr.  The bottom line is that a 30 minute walk most days of the week, the current national guideline, is also a good level for fertility.

New over-the-counter male fertility test available

Wednesday, March 14th, 2012

According to an article in the Wall Street Journal even when couples are grappling with infertility, many men balk at getting their sperm count checked. Now, an over-the-counter product enables them to check their count without a trip to the doctor.

SpermCheck Fertility promises to spot potential problems with male fertility in just about 10 minutes, potentially avoiding unneeded visits by women to the gynecologist or obstetrician, according to its owner and distributor. They claim the tests are 98% accurate, based on independent tests that were submitted to the FDA. Still, urologists caution that SpermCheck only measures one potential cause of male fertility. Sperm count "is just one of several parameters that's looked at when we look at male fertility," said Arthur Tarantino, president of the American Association of Clinical Urologists, adding male infertility could also occur due to the sperm's movement or shape.

And that's precisely the point. If couples believe that getting a good result from this limited test rules out a male factor it may lead to a delay in dealing with a major cause of their infertility.

My advice-don't waste your $ 39. Spend a little more and you can get a full semen analysis at a good reproductive lab.

Mind-Body Wellness Workshop this weekend in South Bay

Wednesday, March 7th, 2012

There will be an intensive short Mind-Body-Wellness workshop in the South Bay of Los Angeles this weekend,  March 10-11th facilitated by Paula Dowd.

For more information please link to  www.mindbodywellnessla.com or feel free to call at 310.373.WELL (9355).

Male Infertility: Eat your vegetables, improve your sperm

Saturday, March 3rd, 2012

This is one of a series of news items from abstracts of studies presented at the Annual Meeting of the American Society for Reproductive Medicine as complied by Dr. David Meldrum, Scientific Director of Reproductive Partners. We appreciate the enormous amount of work it takes to compile and comment on these abstracts.


In normal men, a “prudent diet”, characterized by high intakes of fish, fruit, vegetables, legumes, and whole grains, was associated with improved sperm motility. Antioxidants improve sperm motility in infertile men with reduced motility and may account for this finding. A poor diet appears to be a contributing cause of male infertility.

So eat your veggies.